Tissue-Type Plasminogen Activator and Tenecteplase-Mediated Increase in Blood Brain Barrier Permeability Involves Cell Intrinsic Complement

Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage. t-PA can also influence the CNS in part by modulation of BBB permeability. Complement a...

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Publicat a:Front Neurol
Autors principals: Keragala, Charithani B., Woodruff, Trent M., Liu, Zikou, Niego, Be'eri, Ho, Heidi, McQuilten, Zoe, Medcalf, Robert L.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Neurology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753024/
https://ncbi.nlm.nih.gov/pubmed/33363504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.577272
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