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Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells
Sirolimus (rapamycin) is an immunosuppressive drug used in transplantation. One of its major side effects is the increased risk of diabetes mellitus; however, the exact mechanisms underlying such association have not been elucidated. Here we show that sirolimus impairs glucose-stimulated insulin sec...
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| Publicado no: | Sci Rep |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5696524/ https://ncbi.nlm.nih.gov/pubmed/29158477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15283-y |
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