The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors

We have recently demonstrated that the amino-terminal domain of G protein coupled receptor kinase (GRK) type 5, (GRK5-NT) inhibits NFκB activity in cardiac cells leading to a significant amelioration of LVH. Since GRK5-NT is known to bind calmodulin, this study aimed to evaluate the functional role...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Sorriento, Daniela, Santulli, Gaetano, Ciccarelli, Michele, Maione, Angela Serena, Illario, Maddalena, Trimarco, Bruno, Iaccarino, Guido
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877722/
https://ncbi.nlm.nih.gov/pubmed/29543709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19030861
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