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Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure

BACKGROUND: One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not been fully clarified. METHODS: We studied the effects of the therapeutic dose...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Commun Signal
Asıl Yazarlar: Lombardi, Angela, Trimarco, Bruno, Iaccarino, Guido, Santulli, Gaetano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684747/
https://ncbi.nlm.nih.gov/pubmed/29132395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0203-0
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