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Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the vessel to rupture. Recombinant DCN fusion protein...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Shen, Yue, Russo, Valerio, Zeglinski, Matthew R., Sellers, Stephanie L., Wu, Zhengguo, Oram, Cameron, Santacruz, Stephanie, Merkulova, Yulia, Turner, Christopher, Tauh, Keerit, Zhao, Hongyan, Bozin, Tatjana, Bohunek, Lubos, Zeng, Haishan, Seidman, Michael A., Bleackley, R. Chris, McManus, Bruce M., Ruoslahti, Erkki, Järvinen, Tero A. H., Granville, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696466/
https://ncbi.nlm.nih.gov/pubmed/29158532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16194-8
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