Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function in fibroblasts. Here, we show that miR-29 promotes pathologic hypertrophy of...

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Vydáno v:Nat Commun
Hlavní autoři: Sassi, Yassine, Avramopoulos, Petros, Ramanujam, Deepak, Grüter, Laurenz, Werfel, Stanislas, Giosele, Simon, Brunner, Andreas-David, Esfandyari, Dena, Papadopoulou, Aikaterini S., De Strooper, Bart, Hübner, Norbert, Kumarswamy, Regalla, Thum, Thomas, Yin, Xiaoke, Mayr, Manuel, Laggerbauer, Bernhard, Engelhardt, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696364/
https://ncbi.nlm.nih.gov/pubmed/29158499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01737-4
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