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Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A–G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and BoNT/C1, binds an...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Sicai, Berntsson, Ronnie P.-A., Tepp, William H., Tao, Liang, Johnson, Eric A., Stenmark, Pål, Dong, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696347/
https://ncbi.nlm.nih.gov/pubmed/29158482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01534-z
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