Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Ash1 is a Trithorax group protein that possesses H3K36-specific histone methyltransferase activity, which antagonizes Polycomb silencing. Here we report the identification of two Ash1 complex subunits, Mrg15 and Nurf55. In vitro, Mrg15 stimulates the enzymatic activity of Ash1. In vivo, Mrg15 is rec...

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Udgivet i:Nat Commun
Main Authors: Huang, Chang, Yang, Fu, Zhang, Zhuqiang, Zhang, Jing, Cai, Gaihong, Li, Lin, Zheng, Yong, Chen, She, Xi, Rongwen, Zhu, Bing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696344/
https://ncbi.nlm.nih.gov/pubmed/29158494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01897-3
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