Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Ash1 is a Trithorax group protein that possesses H3K36-specific histone methyltransferase activity, which antagonizes Polycomb silencing. Here we report the identification of two Ash1 complex subunits, Mrg15 and Nurf55. In vitro, Mrg15 stimulates the enzymatic activity of Ash1. In vivo, Mrg15 is rec...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Huang, Chang, Yang, Fu, Zhang, Zhuqiang, Zhang, Jing, Cai, Gaihong, Li, Lin, Zheng, Yong, Chen, She, Xi, Rongwen, Zhu, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696344/
https://ncbi.nlm.nih.gov/pubmed/29158494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01897-3
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