Nuclear microenvironments modulate transcription from low-affinity enhancers

Transcription factors bind low-affinity DNA sequences for only short durations. It is not clear how brief, low-affinity interactions can drive efficient transcription. Here, we report that the transcription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaster...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Tsai, Albert, Muthusamy, Anand K, Alves, Mariana RP, Lavis, Luke D, Singer, Robert H, Stern, David L, Crocker, Justin
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695909/
https://ncbi.nlm.nih.gov/pubmed/29095143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28975
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