Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab(Prx1) mice tibiae: a mouse model of premature aging

Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (Gorab(Prx1)) was generated in which the Gorab gene was deleted in long bones. We ex...

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Detalhes bibliográficos
Publicado no:J Biomech
Main Authors: Yang, Haisheng, Albiol, Laia, Chan, Wing-Lee, Wulsten, Dag, Seliger, Anne, Thelen, Michael, Thiele, Tobias, Spevak, Lyudmila, Boskey, Adele, Kornak, Uwe, Checa, Sara, Willie, Bettina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695220/
https://ncbi.nlm.nih.gov/pubmed/29108851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2017.10.018
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