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Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression
Bone adaptation optimizes mass and structure, but the mechano-response is already reduced at maturation. Downregulation of sclerostin was believed to be a mandatory step in mechano-adaptation, but in young mice it was shown that load-induced formation can occur independent of sclerostin, a product o...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572735/ https://ncbi.nlm.nih.gov/pubmed/28842678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09653-9 |
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