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Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab(Prx1) mice tibiae: a mouse model of premature aging
Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (Gorab(Prx1)) was generated in which the Gorab gene was deleted in long bones. We ex...
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| Опубликовано в: : | J Biomech |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5695220/ https://ncbi.nlm.nih.gov/pubmed/29108851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2017.10.018 |
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