Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic Resistance

Rationale: Minority drug-resistant Mycobacterium tuberculosis subpopulations can be associated with phenotypic resistance but are poorly detected by Sanger sequencing or commercial molecular diagnostic assays. Objectives: To determine the role of targeted next-generation sequencing in resolving thes...

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Publicat a:Am J Respir Crit Care Med
Autors principals: Metcalfe, John Z., Streicher, Elizabeth, Theron, Grant, Colman, Rebecca E., Allender, Christopher, Lemmer, Darrin, Warren, Rob, Engelthaler, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2017
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694839/
https://ncbi.nlm.nih.gov/pubmed/28614668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201703-0556OC
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