ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

ALC1/CHD1L is a member of the SNF2 superfamily of ATPases carrying a macrodomain that binds poly(ADP-ribose). Poly(ADP-ribose) polymerase (PARP) 1 and 2 synthesize poly(ADP-ribose) at DNA-strand cleavage sites, promoting base excision repair (BER). Although depletion of ALC1 causes increased sensiti...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tsuda, Masataka, Cho, Kosai, Ooka, Masato, Shimizu, Naoto, Watanabe, Reiko, Yasui, Akira, Nakazawa, Yuka, Ogi, Tomoo, Harada, Hiroshi, Agama, Keli, Nakamura, Jun, Asada, Ryuta, Fujiike, Haruna, Sakuma, Tetsushi, Yamamoto, Takashi, Murai, Junko, Hiraoka, Masahiro, Koike, Kaoru, Pommier, Yves, Takeda, Shunichi, Hirota, Kouji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693467/
https://ncbi.nlm.nih.gov/pubmed/29149203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188320
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