Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120

Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that caused infection. We analyzed 480 HIV-1 genomes sa...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: deCamp, Allan C., Rolland, Morgane, Edlefsen, Paul T., Sanders-Buell, Eric, Hall, Breana, Magaret, Craig A., Fiore-Gartland, Andrew J., Juraska, Michal, Carpp, Lindsay N., Karuna, Shelly T., Bose, Meera, LePore, Steven, Miller, Shana, O'Sullivan, Annemarie, Poltavee, Kultida, Bai, Hongjun, Dommaraju, Kalpana, Zhao, Hong, Wong, Kim, Chen, Lennie, Ahmed, Hasan, Goodman, Derrick, Tay, Matthew Z., Gottardo, Raphael, Koup, Richard A., Bailer, Robert, Mascola, John R., Graham, Barney S., Roederer, Mario, O’Connell, Robert J., Michael, Nelson L., Robb, Merlin L., Adams, Elizabeth, D’Souza, Patricia, Kublin, James, Corey, Lawrence, Geraghty, Daniel E., Frahm, Nicole, Tomaras, Georgia D., McElrath, M. Juliana, Frenkel, Lisa, Styrchak, Sheila, Tovanabutra, Sodsai, Sobieszczyk, Magdalena E., Hammer, Scott M., Kim, Jerome H., Mullins, James I., Gilbert, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693417/
https://ncbi.nlm.nih.gov/pubmed/29149197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185959
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