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Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is frequently found in colorectal cancer. Loss of APC function results in deregulation of the Wnt/β-catenin signaling pathway causing overexpression of the c-MYC oncogene. In lymphoma, both p19ARF and ribosomal proteins RPL11 and...
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| Publicat a: | Oncogene |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693310/ https://ncbi.nlm.nih.gov/pubmed/27617574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.301 |
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