Spontaneous Mutation of Dock7 Results in Lower Trabecular Bone Mass and Impaired Periosteal Expansion in Aged Female Misty Mice

Misty mice (m/m) have a loss of function mutation in Dock7 gene, a guanine nucleotide exchange factor, resulting in low bone mineral density, uncoupled bone remodeling and reduced bone formation. Dock7 has been identified as a modulator of osteoblast number and in vitro osteogenic differentiation in...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Le, Phuong T, Bishop, Kathleen A, Maridas, David E, Motyl, Katherine J, Brooks, Daniel J, Nagano, Kenichi, Baron, Roland, Bouxsein, Mary L, Rosen, Clifford J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693233/
https://ncbi.nlm.nih.gov/pubmed/28821457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.08.006
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