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Spontaneous Mutation of Dock7 Results in Lower Trabecular Bone Mass and Impaired Periosteal Expansion in Aged Female Misty Mice
Misty mice (m/m) have a loss of function mutation in Dock7 gene, a guanine nucleotide exchange factor, resulting in low bone mineral density, uncoupled bone remodeling and reduced bone formation. Dock7 has been identified as a modulator of osteoblast number and in vitro osteogenic differentiation in...
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| Pubblicato in: | Bone |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693233/ https://ncbi.nlm.nih.gov/pubmed/28821457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.08.006 |
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