IMMU-38. GLIOBLASTOMA-DERIVED IL-6 INDUCES IMMUNOSUPPRESSIVE PERIPHERAL MYELOID CELL PD-L1 EXPRESSION AND TUMOR PROGRESSION

INTRODUCTION: Peripheral myeloid cell PD-L1 expression has been identified as a biomarker of systemic immunosuppression and predictor of vaccine efficacy in GBM. While GBM secreted factors are known to induce an immunosuppressive myeloid phenotype, the specific cytokines regulating PD-L1 remain unid...

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Publié dans:Neuro Oncol
Auteurs principaux: Lamano, Jonathan, Lamano, Jason, Choy, Winward, Veliceasa, Dorina, DiDomenico, Joseph, Oyon, Daniel, Quaggin-Smith, Jessica, Fakurnejad, Shayan, Ampie, Leonel, Li, Derek, Kesavabhotla, Kartik, Kaur, Rajwant, James, C David, Parsa, Andrew, Bloch, Orin
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692960/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.496
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