Glioblastoma-Derived IL-6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth

PURPOSE: Upregulation of programmed death-ligand 1 (PD-L1) on circulating and tumor-infiltrating myeloid cells is a critical component of GBM-mediated immunosuppression that has been associated with diminished response to vaccine immunotherapy and poor survival. While GBM-derived soluble factors hav...

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Publicado no:Clin Cancer Res
Main Authors: Lamano, Jonathan B., Lamano, Jason B., Li, Yuping D., DiDomenico, Joseph D., Choy, Winward, Veliceasa, Dorina, Oyon, Daniel E., Fakurnejad, Shayan, Ampie, Leonel, Kesavabhotla, Kartik, Kaur, Rajwant, Kaur, Gurvinder, Biyashev, Dauren, Unruh, Dusten J., Horbinski, Craig M., James, C. David, Parsa, Andrew T., Bloch, Orin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571046/
https://ncbi.nlm.nih.gov/pubmed/30824583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2402
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