PDTM-19. TOCA 511 & TOCA FC: PRE-CLINICAL PROOF OF CONCEPT IN MEDULLOBLASTOMA

Toca 511, a clinical-stage retroviral replicating vector (RRV) encoding an optimized yeast cytosine deaminase (CD) prodrug activator gene, in combination with Toca FC (extended-release 5-fluorocytosine (5-FC)), is designed to produce 5-FU which kills cancer cells and immune-suppressive myeloid cells...

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Publicat a:Neuro Oncol
Autors principals: Richardson, Angela M, Collins, Sara A, Inagaki, Akihito, Armstrong, Valerie L, Roussel, Martine, Jolly, Douglas, Robbins, David J, Ayad, Nagi, Kasahara, Noriyuki
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692944/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.783
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