IMMU-12. THE HISTONE DEACETYLASE INHIBITOR VALPROIC ACID AUGMENTS THE SUSCEPTIBILITY OF ONCOLYTIC VIRUS-INFECTED GLIOBLASTOMA CELLS TO PD-1 BLOCKADE THERAPY

Oncolytic Herpes Simplex Virus-1(oHSV1) is currently being tested in clinical trials for the treatment of recurrent glioblastoma. Our group has previously shown that valproic acid (VPA), a pan Histone Deacetylase inhibitor (panHDACi) increases the cytotoxic effect of oHSV within tumor cells. VPA has...

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Vydáno v:Neuro Oncol
Hlavní autoři: Alayo, Quazim, Passaro, Carmela, McNulty, John, Hiroshi, Nakashima, Chiocca, E Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692912/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.471
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