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IMMU-12. THE HISTONE DEACETYLASE INHIBITOR VALPROIC ACID AUGMENTS THE SUSCEPTIBILITY OF ONCOLYTIC VIRUS-INFECTED GLIOBLASTOMA CELLS TO PD-1 BLOCKADE THERAPY
Oncolytic Herpes Simplex Virus-1(oHSV1) is currently being tested in clinical trials for the treatment of recurrent glioblastoma. Our group has previously shown that valproic acid (VPA), a pan Histone Deacetylase inhibitor (panHDACi) increases the cytotoxic effect of oHSV within tumor cells. VPA has...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692912/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.471 |
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