EXTH-14. THE ALKYLATING CHEMOTHERAPEUTIC TEMOZOLOMIDE INDUCES METABOLIC STRESS AND POTENTIATES NAD+ DEPLETION-MEDIATED CELL DEATH IN IDH1 MUTANT CANCERS

Mutant IDH1 suppresses normal IDH1 activity and alters the cellular metabolic microenvironment. We have previously identified that steady-state NAD+ level is decreased in endogenous IDH1 mutant cancers. Additionally, we found that inhibitors of the NAD+ biosynthesis enzyme nicotinamide phosphoribosy...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Tateishi, Kensuke, Miller, Julie, Higuchi, Fumi, Koerner, Mara V A, Lelic, Nina, Curry, William, Batchelor, Tracy, Wakimoto, Hiroaki, Chi, Andrew S, Cahill, Daniel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692767/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.309
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