ACTR-16. RESULTS OF THE OPARATIC TRIAL: A PHASE I DOSE ESCALATION STUDY OF OLAPARIB IN COMBINATION WITH TEMOZOLOMIDE (TMZ) IN PATIENTS WITH RELAPSED GLIOBLASTOMA (GBM)

BACKGROUND: Olaparib, a small molecule inhibitor of poly(ADP-ribose) polymerase (PARP), may improve GBM outcomes by enhancing the cytotoxic effects of ionising radiation and TMZ. Clinical development of PARP inhibitors in combination with chemotherapy has been restricted by exacerbation of haematolo...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Chalmers, Anthony, Cruickshank, Garth, Dunn, Laurence, Erridge, Sara, Godfrey, Lisa, Herbert, Christopher, Jefferies, Sarah, Lopez, Juanita, McBain, Catherine, Pittman, Marc, Sleigh, Rebecca, Watts, Colin, Webster-Smith, Mark, Halford, Sarah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Abstracts
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692745/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.012
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