ACTR-16. RESULTS OF THE OPARATIC TRIAL: A PHASE I DOSE ESCALATION STUDY OF OLAPARIB IN COMBINATION WITH TEMOZOLOMIDE (TMZ) IN PATIENTS WITH RELAPSED GLIOBLASTOMA (GBM)

BACKGROUND: Olaparib, a small molecule inhibitor of poly(ADP-ribose) polymerase (PARP), may improve GBM outcomes by enhancing the cytotoxic effects of ionising radiation and TMZ. Clinical development of PARP inhibitors in combination with chemotherapy has been restricted by exacerbation of haematolo...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chalmers, Anthony, Cruickshank, Garth, Dunn, Laurence, Erridge, Sara, Godfrey, Lisa, Herbert, Christopher, Jefferies, Sarah, Lopez, Juanita, McBain, Catherine, Pittman, Marc, Sleigh, Rebecca, Watts, Colin, Webster-Smith, Mark, Halford, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692745/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.012
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