OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth()()

Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug resistance. We have assessed a novel nitrone-based agent, OKN-007, and found it to be effective in decreasing tumor volumes and increasing sur...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Oncol
Prif Awduron: Towner, Rheal A., Smith, Nataliya, Saunders, Debra, Brown, Chase A., Cai, Xue, Ziegler, Jadith, Mallory, Samantha, Dozmorov, Mikhail G., Coutinho De Souza, Patricia, Wiley, Graham, Kim, Kyeongsoon, Kang, Shinwook, Kong, Doo-Sik, Kim, Young-Tae, Fung, Kar-Ming, Wren, Jonathan D., Battiste, James
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2018
Pynciau:
Original article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251232/
https://ncbi.nlm.nih.gov/pubmed/30468988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.10.002
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