Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors

Resetting of G-protein–coupled receptors (GPCRs) from their active state back to their biologically inert ground state is an integral part of GPCR signaling. This “on–off” GPCR cycle is regulated by reversible phosphorylation. Retinal rod and cone photoreceptors arguably represent the best-understoo...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kolesnikov, Alexander V., Orban, Tivadar, Jin, Hui, Brooks, Celine, Hofmann, Lukas, Dong, Zhiqian, Sokolov, Maxim, Palczewski, Krzysztof, Kefalov, Vladimir J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692576/
https://ncbi.nlm.nih.gov/pubmed/29078372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712405114
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