Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

Uncoupling protein 1 (UCP1) is localized on the inner mitochondrial membrane and generates heat by uncoupling ATP synthesis from proton transit across the inner membrane. UCP1 is a key element of nonshivering thermogenesis and is most likely important in the regulation of body adiposity. Pigs (Artio...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zheng, Qiantao, Lin, Jun, Huang, Jiaojiao, Zhang, Hongyong, Zhang, Rui, Zhang, Xueying, Cao, Chunwei, Hambly, Catherine, Qin, Guosong, Yao, Jing, Song, Ruigao, Jia, Qitao, Wang, Xiao, Li, Yongshun, Zhang, Nan, Piao, Zhengyu, Ye, Rongcai, Speakman, John R., Wang, Hongmei, Zhou, Qi, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
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PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692550/
https://ncbi.nlm.nih.gov/pubmed/29078316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707853114
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