Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production

Anti-VEGF drugs are commonly used for treatment of a variety of cancers in human patients, and they often develop resistance. The mechanisms underlying anti-VEGF resistance in human cancer patients are largely unknown. Here, we show that in mouse tumor models and in human cancer patients, the anti-V...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nakamura, Masaki, Zhang, Yin, Yang, Yunlong, Sonmez, Ceylan, Zheng, Wenyi, Huang, Guichun, Seki, Takahiro, Iwamoto, Hideki, Ding, Bo, Yin, Linlin, Foukakis, Theodoros, Hatschek, Thomas, Li, Xuri, Hosaka, Kayoko, Li, Jiaping, Yu, Guohua, Wang, Xinsheng, Liu, Yizhi, Cao, Yihai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692529/
https://ncbi.nlm.nih.gov/pubmed/29078273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703431114
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