PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF MYC-AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

Group 3, MYC-amplified medulloblastomas (MB) remain exceedingly difficult to treat despite maximum tolerable doses of chemotherapy and radiation. Additionally, strategies to directly target MYC are not readily available for clinical use in pediatrics. Thus, to identify novel genetic dependencies and...

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Publicat a:Neuro Oncol
Autors principals: Henderson, Jacob, Cho, Hyeyoung, Davare, Monika, Tsherniak, Aviad, Cowley, Glenn, Weir, Barbara, Hahn, William C, Cho, Yoon-Jae
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692292/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.799
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