CSIG-36. DECREASED CAPICUA (CIC) ENHANCES ONCOGENIC ETV4 SIGNALING IN A MOUSE MODEL OF ASTROCYTOMA AND GLIOMA STEM CELLS

High grade astrocytomas are brain tumors that currently have no cure. Understanding mechanisms that sustain and help them to resist therapy are urgently necessary. The capicua (CIC) transcriptional repressor is a target of receptor tyrosine kinase (RTK) signaling. Upon phosphorylation by RTK signali...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Ramkissoon, Annmarie, Smith, Amanda, Merk, Alexander, Salloum, Ralph, Wan, Ying-Wooi, Minata, Mutsuko, Nakano, Ichiro, Fuller, Christine, Liu, Zhandong, Chow, Lionel M L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692153/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.230
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