PDTM-40. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER.

Pediatric low-grade gliomas (PLGGs) are the most common brain tumors in children mainly defined by activating gene fusions that dysregulate the mitogen-associated protein kinase (MAPK) pathway. Our lab has characterized PLGG-associated KIAA1549-BRAF gene fusion along with response to targeted MAPK i...

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Publicado en:Neuro Oncol
Main Authors: Jain, Payal, Fierst, Tamara, Han, Harry, Smith, Tiffany, Storm, Phillip B, Waanders, Angela J, Resnick, Adam C
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692105/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.803
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