LGG-09. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER

Pediatric low-grade gliomas (PLGGs) are the most common brain tumors in children mainly defined by activating gene fusions that dysregulate the mitogen-associated protein kinase (MAPK) pathway. Our lab has characterized the molecular mechanism of PLGG-associated KIAA1549-BRAF gene fusion and respons...

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發表在:Neuro Oncol
Main Authors: Jain, Payal, Fierst, Tamara M., Han, Harry, Smith, Tiffany, Storm, Phillip J., Waanders, Angela J., Resnick, Adam C.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475131/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.142
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