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ACTR-82. LASER INTERSTITIAL THERMAL THERAPY (LITT) OF RECURRENT GLIOBLASTOMA (GBM) INDUCES TEMPORARY DISRUPTION OF THE PERITUMORAL BLOOD BRAIN BARRIER (BBB) AND MAY IMPROVE EFFICACY OF CHEMOTHERAPY WITH POOR CNS PENETRATION

BACKGROUND: Inadequate drug delivery across the BBB is a major limiting factor in brain cancer therapy. Since most GBM recurrences occur within the peritumoral region where infiltrating glioma cells reside, peritumoral BBB disruption may help improve drug delivery and efficacy. LITT, a minimally inv...

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Foilsithe in:Neuro Oncol
Main Authors: Tran, David, Leuthardt, Eric, Shimony, Joshua, Kim, Albert, Ansstas, George, Campian, Jian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692079/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.068
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