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EXTH-24. MGMT INHIBITION BY DISULFIRAM/COPPER COMPLEX RESTORES VELIPARIB ENHANCING TEMOZOLOMIDE EFFECT IN UNFAVORABLE GLIOBLASTOMA MULTIFORME
O(6) methylguanine DNA methyltransferase (MGMT), a DNA repair enzyme, is over expressed in majority of glioblastoma multiforme (GBM) patients. MGMT overexpression causes temozolomide (TMZ) resistance. Poly (ADP – ribose) polymerase (PARP), another early DNA damage response system, like MGMT, has mul...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692012/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.318 |
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