DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

Self-assembly of HIV-1 integrase (IN) in solution has been studied previously by time-resolved fluorescence, using tryptophan anisotropy decay. This approach provides information on the size of macromolecules via the determination of rotational correlation times (θ). We have shown that, at submicrom...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Deprez, Eric, Tauc, Patrick, Leh, Hervé, Mouscadet, Jean-François, Auclair, Christian, Hawkins, Mary E., Brochon, Jean-Claude
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2001
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC56920/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.181024498
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