DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

Self-assembly of HIV-1 integrase (IN) in solution has been studied previously by time-resolved fluorescence, using tryptophan anisotropy decay. This approach provides information on the size of macromolecules via the determination of rotational correlation times (θ). We have shown that, at submicrom...

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Detalles Bibliográficos
Autores principales: Deprez, Eric, Tauc, Patrick, Leh, Hervé, Mouscadet, Jean-François, Auclair, Christian, Hawkins, Mary E., Brochon, Jean-Claude
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC56920/
https://ncbi.nlm.nih.gov/pubmed/11504911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181024498
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