Replication of Chimeric Human Immunodeficiency Virus Type 1 (HIV-1) Containing HIV-2 Integrase (IN): Naturally Selected Mutations in IN Augment DNA Synthesis

The human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein augments the initiation of reverse transcription. Chimeric HIV-1 containing HIV-2 IN (SG3(IN2)) is severely impaired in virus infectivity and DNA synthesis. To analyze the nature of this defect, we infected T cells with the chime...

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Detalhes bibliográficos
Main Authors: Padow, Marcus, Lai, Lilin, Deivanayagam, Champion, DeLucas, Lawrence J., Weiss, Robert B., Dunn, Diane M., Wu, Xiaoyun, Kappes, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC224969/
https://ncbi.nlm.nih.gov/pubmed/14512553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.20.11050-11059.2003
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