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STEM-05. THE CONSERVED TUMOR SUPPRESSOR LGL1 REGULATES ADULT OLIGODENDROCYTE PROGENITOR CELL DIVISION MODE AND PREVENTS PREMALIGNANT PHENOTYPES
Mammalian oligodendrocyte progenitor cells (OPC) divide asymmetrically by dispatching pro-mitotic NG2, EGFR and PDGFRalpha, from here on called the NG2 complex, unequally between daughter cells to establish a cell fate bias and to restrict proliferation. Studies in genetically engineered mouse model...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691995/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.923 |
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