SC-14 ASYMMETRY-DEFECTIVE OLIGODENDROCYTE PROGENITORS AS POTENTIAL CELL-OF-ORIGIN OF HYPERACTIVATED RAF-INDUCED MALIGNANT ASTROCYTOMAS

BACKGROUND: Studies show that the expression of an activating mutation of BRAF (BRAFV600E) in conjunction with Ink4a/Arf deletion, but not each alteration by itself, lead to formation of malignant astrocytoma (MA)-like tumors. Importantly, BRAFV600E occurs in 39% of pediatric MA and in 7.7% of adult...

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Pubblicato in:Neuro Oncol
Autori principali: Kadkhodaei, Banafsheh, Lerner, Robin G., Sidorov, Maxim, Goméz-López, Sandra, McMahon, Martin, James, David, Petritsch, Claudia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218573/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou275.14
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