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SC-14 ASYMMETRY-DEFECTIVE OLIGODENDROCYTE PROGENITORS AS POTENTIAL CELL-OF-ORIGIN OF HYPERACTIVATED RAF-INDUCED MALIGNANT ASTROCYTOMAS
BACKGROUND: Studies show that the expression of an activating mutation of BRAF (BRAFV600E) in conjunction with Ink4a/Arf deletion, but not each alteration by itself, lead to formation of malignant astrocytoma (MA)-like tumors. Importantly, BRAFV600E occurs in 39% of pediatric MA and in 7.7% of adult...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218573/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou275.14 |
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