EXTH-58. EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA MODELS IN VITRO AND IN VIVO

INTRODUCTION: MLN0128, a second-generation ATP-competitive pan-mTOR kinase inhibitor, acts on both mTORC1 and mTORC2. We investigated the effects of MLN0128 monotherapy and in combination with MEK and BRAF(V600E) inhibition in models of pediatric low-grade glioma (PLGG). METHODS: We used human gliom...

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Pubblicato in:Neuro Oncol
Autori principali: Liu, Kevin X, Mueller, Sabine, Dik, Rogier, Yang, Xiaodong, DuBois, Steven, Waanders, Angela J, Resnick, Adam C, Weiss, William A, Haas-Kogan, Daphne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691939/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.350
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