Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer

The R2 subunits of class I ribonucleotide reductases (RNRs) house a diferric-tyrosyl radical (Y·) cofactor essential for DNA synthesis. In yeast, there are two R2 proteins, Y2 and Y4. Although both Y2 and Y4 are homologous to R2s from other organisms, Y4 lacks three conserved iron-binding residues,...

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Bibliographic Details
Main Authors: Voegtli, Walter C., Ge, Jie, Perlstein, Deborah L., Stubbe, JoAnne, Rosenzweig, Amy C.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC56917/
https://ncbi.nlm.nih.gov/pubmed/11526233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181336398
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