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The energy cost of polypeptide knot formation and its folding consequences
Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain—an event that can potentially impair its folding—and about the effect of a knot on the stability and folding kinetics of a protein. Here we used optical tweezers to show that the free...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691195/ https://ncbi.nlm.nih.gov/pubmed/29146980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01691-1 |
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