Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

PURPOSE: Bevacizumab, a humanized monoclonal antibody to VEGF, is used routinely in the treatment of patients with recurrent glioblastoma (GBM). However, very little is known regarding the effects of bevacizumab on the cells in the perivascular space in tumors. EXPERIMENTAL DESIGN: Established ortho...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Müller-Greven, Gaëlle, Carlin, Cathleen R., Burgett, Monica E., Ahluwalia, Manmeet S., Lauko, Adam, Nowacki, Amy S., Herting, Cameron J., Qadan, Maha A., Bredel, Markus, Toms, Steven A., Lathia, Justin D., Hambardzumyan, Dolores, Sarkaria, Jann N., Hamerlik, Petra, Gladson, Candece L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690835/
https://ncbi.nlm.nih.gov/pubmed/28912141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0249
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