Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

PURPOSE: Bevacizumab, a humanized monoclonal antibody to VEGF, is used routinely in the treatment of patients with recurrent glioblastoma (GBM). However, very little is known regarding the effects of bevacizumab on the cells in the perivascular space in tumors. EXPERIMENTAL DESIGN: Established ortho...

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Publicado no:Clin Cancer Res
Main Authors: Müller-Greven, Gaëlle, Carlin, Cathleen R., Burgett, Monica E., Ahluwalia, Manmeet S., Lauko, Adam, Nowacki, Amy S., Herting, Cameron J., Qadan, Maha A., Bredel, Markus, Toms, Steven A., Lathia, Justin D., Hambardzumyan, Dolores, Sarkaria, Jann N., Hamerlik, Petra, Gladson, Candece L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690835/
https://ncbi.nlm.nih.gov/pubmed/28912141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0249
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