Macrophages facilitate resistance to anti-VEGF therapy by altered VEGFR expression

PURPOSE: VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly understood. EXPERIMENTAL DESIGN: To evaluate the potential role of immune cells in the development of resistance to VEGF blockade, we firs...

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Pubblicato in:Clin Cancer Res
Autori principali: Dalton, Heather J., Pradeep, Sunila, McGuire, Michael, Hailemichael, Yared, Shaolin, MA, Lyons, Yasmin, Armaiz-Pena, Guillermo N., Previs, Rebecca A., Hansen, Jean Marie, Rupaimoole, Rajesha, Gonzalez-Villasana, Vianey, Cho, Min Soon, Wu, Sherry, Mangala, Lingegowda S., Jennings, Nicholas B., Hu, Wei, Langley, Robert, Mu, Hong, Andreeff, Michael, Bar-Eli, Menashe, Overwijk, Willem, Ram, Prahlad, Lopez-Berestein, Gabriel, Coleman, Robert L., Sood, Anil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690831/
https://ncbi.nlm.nih.gov/pubmed/28855350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0647
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