Quantitative measurement and thermodynamic modeling of fused enhancers supports a two-tiered mechanism for interpreting regulatory DNA

Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer as a “bag of sites”. These models fail on endogenous loci that harbor multiple enhancers, and a “two-tier” model appears better suited: in ea...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Samee, Md. Abul Hassan, Lydiard-Martin, Tara, Biette, Kelly M., Vincent, Ben J., Bragdon, Meghan D., Eckenrode, Kelly B., Wunderlich, Zeba, Estrada, Javier, Sinha, Saurabh, DePace, Angela H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690553/
https://ncbi.nlm.nih.gov/pubmed/28978476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.033
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