RNAi screen reveals a role of SPHK2 in dengue virus–mediated apoptosis in hepatic cell lines

Hepatic dysfunction is a feature of dengue virus (DENV) infection. Hepatic biopsy specimens obtained from fatal cases of DENV infection show apoptosis, which relates to the pathogenesis of DENV infection. However, how DENV induced liver injury is not fully understood. In this study, we aim to identi...

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Vydáno v:PLoS One
Hlavní autoři: Morchang, Atthapan, Lee, Regina Ching Hua, Yenchitsomanus, Pa-thai, Sreekanth, Gopinathan Pillai, Noisakran, Sansanee, Chu, Justin Jang Hann, Limjindaporn, Thawornchai
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690425/
https://ncbi.nlm.nih.gov/pubmed/29145490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188121
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